PubMed Top Medical Papers

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Daily top 5 newly-indexed medical papers on PubMed by citation momentum and journal impact factor

PubMed Top Medical Papers2026/05/29 22:23:35

Five papers worth your time — May 28–29, 2026

Five papers indexed on May 28–29, 2026: blood p-tau217/Aβ42 biomarkers detect Alzheimer's pathology in midlife with 4× cognitive-decline risk over 5 years (The Lancet); a 619,372-person GWAS finds the amino acid–diabetes link is likely not causal (Nature); Asian veterans and CNS cancer patients face the highest adjusted suicide risk in a 292K-veteran cohort (JAMA Oncology); speech-in-noise deficits predict accelerated cortical thinning independent of hearing loss (JAMA Otolaryngology); and distinct traffic pollutants (NO2, benzene, lead) drive chronic rhinosinusitis via separate inflammatory pathways (JAMA Otolaryngology).

PubMed Top Medical Papers2026/05/28 22:25:23

Five papers — May 27–28, 2026

BioVAT iPSC-derived heart muscle patches show 4.5 mm wall thickening and 3.9 pp LVEF gain in NEJM Phase 1/2. JAMA accelerometer cohort: >10 h/day sedentary time doubles adverse pregnancy outcome risk. Bridge to HOPE RCT (JAMA Surgery): portal-venous HOPE perfusion cuts early liver allograft dysfunction from 37.3% to 20.2% across 15 US centers. T cell sEV blood test correlates perfectly with lung transplant rejection biopsy in first human validation (Am J Transplant). TP53 loss + interferon signaling reverts lung adenocarcinoma to embryonic branching state, with branching-gene signature predicting treatment response across 1,500+ patients (Molecular Oncology).

PubMed Top Medical Papers2026/05/27 22:30:48

Five papers — May 26–27, 2026

Rogaratinib delivers 41.7% ORR and 31-month median PFS in SDH-deficient GIST — the first effective systemic therapy for this orphan disease (Nature Medicine). Paricalcitol triples partial response rate vs. chemotherapy alone in metastatic pancreatic cancer (Nature Cancer). Ecopipam cuts Tourette relapse risk by 53% in children with Phase 3 data, NDA filing expected this year (JAMA Neurology). KRAS G12V PROTAC degradation regresses lung tumors in mice; resistance emerges via proteasome machinery remodeling (Cancer Research). HPV self-collection raises cervical cancer screening completion by 2.2 pp across 121,000 patients (NEJM Catalyst).

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